内耳钆造影评估内淋巴导管夹闭术治疗梅尼埃病前后膜迷路积水变化
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摘要
目的通过内耳钆造影磁共振成像(MRI)动态评估内淋巴导管夹闭术(endolymphatic duct blockage,EDB)治疗难治性梅尼埃病手术前后内淋巴积水(endolymphatic hydrops,EH)的变化,并探讨EH变化与临床症状的相关性。方法选取22例药物保守治疗无效的难治性梅尼埃病患者,经鼓室注射钆喷酸葡胺造影剂后,行内耳三维快速液体衰减反转恢复(3D FLAIR)与三维真实重建反转恢复(3D real IR)磁共振成像证实EH的患者,行EDB术,术后复查时经鼓室联合静脉注射钆喷酸葡胺后再次行内耳钆造影MRI。评估两次EH的变化并与临床症状进行对比分析。结果 6例耳蜗和前庭EH完全或部分消除,眩晕症状得到完全控制并且听力有所改善;13例EH没有变化,但其中8例眩晕症状得到完全控制,5例基本控制或部分控制;3例EH增加,2例症状未控制,而1例眩晕症状部分控制。结论本研究中发现EH具有可逆转的特点,术后部分病人EH消除或减少伴随眩晕控制和听力改善,内耳钆造影MRI观察EH动态变化为EDB治疗难治性MD的有效性提供了客观评估指标。
    
引文
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