鼓室内注射庆大霉素治疗单侧难治性梅尼埃病的临床效果及安全性
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  • 作者:张静 ; 李希平
  • 关键词:梅尼埃病 ; 庆大霉素 ; 眩晕
  • 中文刊名:中国医药
  • 英文刊名:China Medicine
  • 机构:首都医科大学附属北京安贞医院耳鼻咽喉头颈外科;
  • 出版日期:2020-01-21 09:41
  • 年:2020
  • 期:02
  • 页:143-145
  • CN:11-5451/R
  • ISSN:1673-4777
  • 分类号:R764.33
摘要
目的观察鼓室内注射小剂量庆大霉素治疗难治性梅尼埃病的临床效果及安全性。方法回顾性分析接受鼓室内注射小剂量庆大霉素治疗的单侧难治性梅尼埃病37例患者的临床资料,对治疗前后患者眩晕、纯音听阈及耳鸣的变化进行对比分析。结果治疗后眩晕控制率91. 9%(34/37),其中A级17例、B级11例、C级6例、D级3例、E级0例。治疗后眩晕发作的严重程度及对日常生活的影响显著改善,分级全部下降,有效率100%(37/37)。治疗后言语听阈提高> 15 d B者3例,占8. 1%,治疗后言语听阈下降> 10 d B者4例,占10. 8%。治疗前患者言语听阈为(60±11) d B,治疗后为(59±11) d B,治疗前后差异无统计学意义(t=0. 576,P=0. 569)。耳鸣痛苦分级治疗前后差异无统计学意义(Z=1. 640,P=0. 110)。结论鼓室内注射小剂量庆大霉素治疗单侧难治性梅尼埃病,可以有效的控制眩晕的发作,降低眩晕发作的严重程度及对生活的影响,且对听力影响小,不会加重耳鸣的程度。
    
引文
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